Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.: Table 1
| trading_symbol | registrant_name | time | price | change | percentage_change | 
|---|---|---|---|---|---|
| AGIO | AGIOS PHARMACEUTICALS, INC. | 2025-10-30 17:02:23 | 43.58 | 0.4 | 0.92 | 
| trading_symbol | central_index_key | registrant_name | isin_number | lei_number | ein_number | exchange | sic_code | sic_description | fiscal_year_end | state_of_incorporation | address_street | address_city | address_state | address_zip_code | address_country | address_country_code | phone_number | mailing_address | business_address | former_name | industry | founding_date | chief_executive_officer | number_of_employees | website | market_cap | shares_issued | shares_outstanding | description | update_time | 
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGIO | 0001439222 | AGIOS PHARMACEUTICALS, INC. | US00847X1046 | 529900ONJHY8EOGYT555 | — | Nasdaq | 2834 | Pharmaceutical Preparations | 1231 | DE | 88 SIDNEY STREET | CAMBRIDGE | MA | 02139 | UNITED STATES | US | 617-649-8600 | 88 SIDNEY STREET, CAMBRIDGE, MA, 02139 | 88 SIDNEY STREET, CAMBRIDGE, MA, 02139 | AGIOS PHARMACEUTICALS INC | — | 2008 | Brian Goff | 536 | http://agios.com | 2,416,161,200 | 74,254,956 | 58,101,518 | Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.: Table 1 | 2025-10-30 13:56:54 | 
| Fiscal Year | Market Cap | Change In Market Cap | Percentage Change In Market Cap | Shares Outstanding | Change In Shares Outstanding | Percentage Change In Shares Outstanding | 
|---|---|---|---|---|---|---|
| 2024 | 2,416,161,200 | 858,375,874 | 55.1023 | 57,296,167 | 1,101,320 | 1.9598 | 
| 2023 | 1,557,785,326 | 357,507,822 | 29.7854 | 56,194,847 | 909,624 | 1.6453 | 
| 2022 | 1,200,277,504 | -2,067,312,497 | -63.2672 | 55,285,223 | 647,722 | 1.1855 | 
| Executive Name | Executive Position | Fiscal Year | Salary | Bonus | Stock Awards | Incentive Plan Compensation | Other Compensation | Total Compensation | 
|---|---|---|---|---|---|---|---|---|
| James Burns | Chief Legal Officer | 2024 | 511,917 | 0 | 548,590 | 287,954 | 15,861 | 2,432,507 | 
| Sarah Gheuens | Chief Medical Officer | 2024 | 583,495 | 0 | 548,590 | 328,216 | 15,861 | 2,544,347 | 
| Brian Goff | Chief Executive Officer | 2024 | 822,198 | 0 | 1,742,580 | 719,423 | 11,653 | 6,776,359 | 
| Cecilia Jones | Chief Financial Officer | 2024 | 503,880 | 0 | 548,590 | 283,433 | 15,261 | 2,419,349 | 
| Tsveta Milanova | Chief Commercial Officer | 2024 | 525,300 | 0 | 548,590 | 295,482 | 15,861 | 2,453,418 | 
| Fiscal Year | Employee Count | 
|---|---|
| 2024 | 486 | 
| 2023 | 383 | 
| 2022 | 389 | 
| Fiscal Year | 2024 | 2023 | 2022 | 
|---|---|---|---|
| Revenue | 36,498,000 | 26,823,000 | 14,240,000 | 
| Cost Of Revenue | 4,165,000 | 2,881,000 | 1,704,000 | 
| Gross Profit | — | — | — | 
| Research And Development Expenses | 301,286,000 | 295,526,000 | 279,910,000 | 
| General And Administrative Expenses | 156,784,000 | 119,903,000 | 121,673,000 | 
| Operating Expenses | 462,235,000 | 418,310,000 | 403,287,000 | 
| Operating Income | -425,737,000 | -391,487,000 | -389,047,000 | 
| Net Income | 673,725,000 | -352,088,000 | -231,801,000 | 
| Earnings Per Share Basic | 11.86 | -6.33 | -4.23 | 
| Earnings Per Share Diluted | 11.64 | -6.33 | -4.23 | 
| Weighted Average Shares Outstanding Basic | 56,807,415 | 55,651,487 | 54,789,435 | 
| Weighted Average Shares Outstanding Diluted | 57,889,255 | 55,651,487 | 54,789,435 | 
| Fiscal Year | 2024 | 2023 | 2022 | 
|---|---|---|---|
| Cash And Cash Equivalents | 76,247,000 | 88,205,000 | 139,259,000 | 
| Marketable Securities Current | 817,463,000 | 688,723,000 | 643,860,000 | 
| Accounts Receivable | 4,109,000 | 2,810,000 | 2,206,000 | 
| Inventories | 27,616,000 | 19,076,000 | 8,492,000 | 
| Non Trade Receivables | 900,000 | 1,100,000 | 300,000 | 
| Other Assets Current | — | — | — | 
| Total Assets Current | 965,600,000 | 833,835,000 | 832,772,000 | 
| Marketable Securities Non Current | 638,321,000 | 29,435,000 | 313,874,000 | 
| Property Plant And Equipment | 11,675,000 | 15,382,000 | 22,987,000 | 
| Other Assets Non Current | 4,724,000 | 4,057,000 | 3,956,000 | 
| Total Assets Non Current | 697,599,000 | 103,283,000 | 405,946,000 | 
| Total Assets | 1,663,199,000 | 937,118,000 | 1,238,718,000 | 
| Accounts Payable | 16,643,000 | 9,780,000 | 18,616,000 | 
| Deferred Revenue | — | — | — | 
| Short Term Debt | — | — | — | 
| Other Liabilities Current | 46,861,000 | 43,167,000 | 30,350,000 | 
| Total Liabilities Current | 81,156,000 | 67,955,000 | 62,629,000 | 
| Long Term Debt | — | — | — | 
| Other Liabilities Non Current | 880,000 | 1,156,000 | 3,279,000 | 
| Total Liabilities Non Current | 41,087,000 | 58,144,000 | 75,275,000 | 
| Total Liabilities | 122,243,000 | 126,099,000 | 137,904,000 | 
| Common Stock | 73,000 | 72,000 | 71,000 | 
| Retained Earnings | -148,924,000 | -822,649,000 | -470,561,000 | 
| Accumulated Other Comprehensive Income | — | — | — | 
| Total Shareholders Equity | 1,540,956,000 | 811,019,000 | 1,100,814,000 | 
| Fiscal Year | 2024 | 2023 | 2022 | 
|---|---|---|---|
| Depreciation And Amortization | 5,700,000 | 6,600,000 | 8,400,000 | 
| Share Based Compensation Expense | 42,847,000 | 44,766,000 | 49,296,000 | 
| Other Non Cash Income Expense | 39,000 | -553,000 | 48,000 | 
| Change In Accounts Receivable | 1,299,000 | 604,000 | 2,206,000 | 
| Change In Inventories | 8,540,000 | 10,584,000 | 8,492,000 | 
| Change In Non Trade Receivables | — | — | — | 
| Change In Other Assets | — | — | — | 
| Change In Accounts Payable | 6,601,000 | -8,733,000 | 3,436,000 | 
| Change In Other Liabilities | -276,000 | -2,123,000 | 3,003,000 | 
| Cash From Operating Activities | -389,841,000 | -296,062,000 | -309,478,000 | 
| Purchases Of Marketable Securities | 1,542,433,000 | 417,930,000 | 1,030,781,000 | 
| Sales Of Marketable Securities | 818,383,000 | 674,679,000 | 1,146,175,000 | 
| Acquisition Of Property Plant And Equipment | 1,685,000 | 999,000 | 4,881,000 | 
| Acquisition Of Business | — | — | — | 
| Other Investing Activities | — | — | — | 
| Cash From Investing Activities | 363,441,000 | 239,575,000 | 243,261,000 | 
| Tax Withholding For Share Based Compensation | — | — | — | 
| Payments Of Dividends | — | — | — | 
| Issuance Of Common Stock | — | — | — | 
| Repurchase Of Common Stock | — | — | — | 
| Issuance Of Long Term Debt | — | — | — | 
| Repayment Of Long Term Debt | — | — | — | 
| Other Financing Activities | 14,442,000 | 5,433,000 | 2,681,000 | 
| Cash From Financing Activities | 14,442,000 | 5,433,000 | 2,350,000 | 
| Change In Cash | -11,958,000 | -51,054,000 | -63,867,000 | 
| Cash At End Of Period | 76,247,000 | 88,205,000 | 139,259,000 | 
| Income Taxes Paid | 43,150,000 | 1,569,000 | 0 | 
| Interest Paid | — | — | — | 
| Fiscal Year | 2024 | 2023 | 2022 | 
|---|---|---|---|
| Earnings Per Share | 11.86 | -6.33 | -4.23 | 
| Price To Earnings Ratio | 2.7707 | -3.5182 | -6.6383 | 
| Earnings Growth Rate | -287.3618 | 49.6454 | -115.9322 | 
| Price Earnings To Growth Ratio | -0.0096 | -0.0709 | 0.0573 | 
| Book Value Per Share | 27.126 | 14.5732 | 20.0917 | 
| Price To Book Ratio | 1.2114 | 1.5281 | 1.3976 | 
| Ebitda | 722,575,000 | -343,919,000 | -223,401,000 | 
| Enterprise Value | — | — | — | 
| Dividend Yield | — | — | — | 
| Dividend Payout Ratio | — | — | — | 
| Debt To Equity Ratio | — | — | — | 
| Capital Expenditures | 1,993,000 | -1,005,000 | 2,464,000 | 
| Free Cash Flow | -391,834,000 | -295,057,000 | -311,942,000 | 
| Return On Equity | 0.4372 | -0.4341 | -0.2106 | 
| One Year Beta | 1.5839 | 1.1323 | 1.5315 | 
| Three Year Beta | 1.4547 | 1.2891 | 1.0379 | 
| Five Year Beta | 1.0827 | 1.0962 | 1.148 | 
| Insider Name | Relationship To Issuer | Transaction Date | Amount Of Securities | Acquired Or Disposed | Securities Owned Following Transaction | 
|---|---|---|---|---|---|
| Gheuens Sarah | Chief Medical Officer | 2025-10-27 | 3,302 | A | 65,029 | 
| Gheuens Sarah | Chief Medical Officer | 2025-10-27 | 3,302 | D | 61,727 | 
| Gheuens Sarah | Chief Medical Officer | 2025-10-27 | 3,302 | D | 28,784 | 
| Scadden David | Director | 2025-10-08 | 200 | A | 17,803 | 
| Scadden David | Director | 2025-10-08 | 200 | D | 17,603 | 
| Name Of Reporting Person | Report Date | State | Transaction Type | Transaction Date | Owner Type | Amount | 
|---|---|---|---|---|---|---|
| Gilbert Cisneros | 2025-05-06 | CA31 | Purchase | 2025-04-17 | — | $1,001 - $15,000 | 
| Gilbert Cisneros | 2025-02-11 | CA31 | Purchase | 2025-01-29 | — | $1,001 - $15,000 | 
| Josh Gottheimer | 2024-02-15 | NJ05 | Purchase | 2024-01-24 | Joint | $1,001 - $15,000 | 
| Thomas MacArthur | 2015-06-07 | NJ03 | Sale | 2015-05-27 | Joint | $1,001 - $15,000 | 
| Thomas MacArthur | 2015-04-11 | NJ03 | Purchase | 2015-03-18 | Joint | $1,001 - $15,000 | 
| Investor Name | Period Of Report | Market Value | Amount Of Securities | Price Per Security | 
|---|---|---|---|---|
| TEACHER RETIREMENT SYSTEM OF TEXAS | 2025-09-30 | 541,247 | 13,484 | 40.1399 | 
| Parkside Financial Bank & Trust | 2025-09-30 | 1,807 | 45 | 40.1556 | 
| Covestor Ltd | 2025-09-30 | 3,000 | 64 | 46.875 | 
| Root Financial Partners, LLC | 2025-09-30 | 4,255 | 106 | 40.1415 | 
| AMALGAMATED BANK | 2025-09-30 | 79,000 | 1,957 | 40.3679 | 
| Registrant Name | Period Of Report | Fund Name | Fund Symbol | Amount Of Units | Value In Usd | Percentage Value Compared To Assets | 
|---|---|---|---|---|---|---|
| Global X Funds | 2025-08-31 | Global X Aging Population ETF | AGNG | 6,794 | 256,201.74 | 0.3974 | 
| SEI INSTITUTIONAL INVESTMENTS TRUST | 2025-08-31 | SIIT Multi-Asset Real Return Fund - Class A | SEIAX | 229 | 8,635.59 | 0.0011 | 
| SEI INSTITUTIONAL INVESTMENTS TRUST | 2025-08-31 | SIIT Extended Market Index Fund - Class A | SMXAX | 7,900 | 297,909 | 0.0246 | 
| ALPS ETF Trust | 2025-08-31 | ALPS Medical Breakthroughs ETF | SBIO | 27,439 | 1,034,724.69 | 1.2777 | 
| Northern Lights Fund Trust IV | 2025-08-31 | Inspire Small/Mid Cap ETF | ISMD | 12,049 | 454,367.79 | 0.2066 |