Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.: Table 1
| trading_symbol | registrant_name | time | price | change | percentage_change |
|---|---|---|---|---|---|
| AGIO | AGIOS PHARMACEUTICALS, INC. | 2026-02-18 05:35:15 | 27.77 | -0.05 | -0.18 |
| trading_symbol | central_index_key | registrant_name | isin_number | lei_number | ein_number | exchange | sic_code | sic_description | fiscal_year_end | state_of_incorporation | address_street | address_city | address_state | address_zip_code | address_country | address_country_code | phone_number | mailing_address | business_address | former_name | industry | founding_date | chief_executive_officer | number_of_employees | website | market_cap | shares_issued | shares_outstanding | description | update_time |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGIO | 0001439222 | AGIOS PHARMACEUTICALS, INC. | US00847X1046 | 529900ONJHY8EOGYT555 | — | Nasdaq | 2834 | Pharmaceutical Preparations | 1231 | DE | 88 SIDNEY STREET | CAMBRIDGE | MA | 02139 | UNITED STATES | US | 617-649-8600 | 88 SIDNEY STREET, CAMBRIDGE, MA, 02139 | 88 SIDNEY STREET, CAMBRIDGE, MA, 02139 | AGIOS PHARMACEUTICALS INC | — | 2008 | Brian Goff | 536 | http://agios.com | 1,914,339,201 | 74,665,003 | 58,592,172 | Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 (or 2007) by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.: Table 1 | 2026-02-12 17:38:16 |
| Fiscal Year | Market Cap | Change In Market Cap | Percentage Change In Market Cap | Shares Outstanding | Change In Shares Outstanding | Percentage Change In Shares Outstanding |
|---|---|---|---|---|---|---|
| 2025 | 1,914,339,201 | -501,821,999 | -20.7694 | 58,592,172 | 1,296,005 | 2.2619 |
| 2024 | 2,416,161,200 | 858,375,874 | 55.1023 | 57,296,167 | 1,101,320 | 1.9598 |
| 2023 | 1,557,785,326 | 357,507,822 | 29.7854 | 56,194,847 | 909,624 | 1.6453 |
| Executive Name | Executive Position | Fiscal Year | Salary | Bonus | Stock Awards | Incentive Plan Compensation | Other Compensation | Total Compensation |
|---|---|---|---|---|---|---|---|---|
| James Burns | Chief Legal Officer | 2024 | 511,917 | 0 | 548,590 | 287,954 | 15,861 | 2,432,507 |
| Sarah Gheuens | Chief Medical Officer | 2024 | 583,495 | 0 | 548,590 | 328,216 | 15,861 | 2,544,347 |
| Brian Goff | Chief Executive Officer | 2024 | 822,198 | 0 | 1,742,580 | 719,423 | 11,653 | 6,776,359 |
| Cecilia Jones | Chief Financial Officer | 2024 | 503,880 | 0 | 548,590 | 283,433 | 15,261 | 2,419,349 |
| Tsveta Milanova | Chief Commercial Officer | 2024 | 525,300 | 0 | 548,590 | 295,482 | 15,861 | 2,453,418 |
| Fiscal Year | Employee Count |
|---|---|
| 2025 | 539 |
| 2024 | 486 |
| 2023 | 383 |
| Fiscal Year | 2025 | 2024 | 2023 |
|---|---|---|---|
| Revenue | 54,028,000 | 36,498,000 | 26,823,000 |
| Cost Of Revenue | 6,345,000 | 4,165,000 | 2,881,000 |
| Gross Profit | — | — | — |
| Research And Development Expenses | 339,535,000 | 301,286,000 | 295,526,000 |
| General And Administrative Expenses | 180,280,000 | 156,784,000 | 119,903,000 |
| Operating Expenses | 526,160,000 | 462,235,000 | 418,310,000 |
| Operating Income | -472,132,000 | -425,737,000 | -391,487,000 |
| Net Income | -412,781,000 | 673,725,000 | -352,088,000 |
| Earnings Per Share Basic | -7.12 | 11.86 | -6.33 |
| Earnings Per Share Diluted | -7.12 | 11.64 | -6.33 |
| Weighted Average Shares Outstanding Basic | 57,972,004 | 56,807,415 | 55,651,487 |
| Weighted Average Shares Outstanding Diluted | 57,972,004 | 57,889,255 | 55,651,487 |
| Fiscal Year | 2025 | 2024 | 2023 |
|---|---|---|---|
| Cash And Cash Equivalents | 89,130,000 | 76,247,000 | 88,205,000 |
| Marketable Securities Current | 765,295,000 | 817,463,000 | 688,723,000 |
| Accounts Receivable | 10,577,000 | 4,109,000 | 2,810,000 |
| Inventories | 32,920,000 | 27,616,000 | 19,076,000 |
| Non Trade Receivables | — | 900,000 | 1,100,000 |
| Other Assets Current | — | — | — |
| Total Assets Current | 942,052,000 | 965,600,000 | 833,835,000 |
| Marketable Securities Non Current | 310,013,000 | 638,321,000 | 29,435,000 |
| Property Plant And Equipment | 10,775,000 | 11,675,000 | 15,382,000 |
| Other Assets Non Current | 3,931,000 | 4,724,000 | 4,057,000 |
| Total Assets Non Current | 355,173,000 | 697,599,000 | 103,283,000 |
| Total Assets | 1,297,225,000 | 1,663,199,000 | 937,118,000 |
| Accounts Payable | 18,355,000 | 16,643,000 | 9,780,000 |
| Deferred Revenue | — | — | — |
| Short Term Debt | — | — | — |
| Other Liabilities Current | 45,459,000 | 46,861,000 | 43,167,000 |
| Total Liabilities Current | 82,206,000 | 81,156,000 | 67,955,000 |
| Long Term Debt | — | — | — |
| Other Liabilities Non Current | 90,000 | 880,000 | 1,156,000 |
| Total Liabilities Non Current | 21,905,000 | 41,087,000 | 58,144,000 |
| Total Liabilities | 104,111,000 | 122,243,000 | 126,099,000 |
| Common Stock | 75,000 | 73,000 | 72,000 |
| Retained Earnings | -561,705,000 | -148,924,000 | -822,649,000 |
| Accumulated Other Comprehensive Income | — | — | — |
| Total Shareholders Equity | 1,193,114,000 | 1,540,956,000 | 811,019,000 |
| Fiscal Year | 2025 | 2024 | 2023 |
|---|---|---|---|
| Depreciation And Amortization | 5,200,000 | 5,700,000 | 6,600,000 |
| Share Based Compensation Expense | 52,552,000 | 42,847,000 | 44,766,000 |
| Other Non Cash Income Expense | -5,000 | 39,000 | -553,000 |
| Change In Accounts Receivable | 6,468,000 | 1,299,000 | 604,000 |
| Change In Inventories | 5,304,000 | 8,540,000 | 10,584,000 |
| Change In Non Trade Receivables | — | — | — |
| Change In Other Assets | — | — | — |
| Change In Accounts Payable | 1,746,000 | 6,601,000 | -8,733,000 |
| Change In Other Liabilities | -790,000 | -276,000 | -2,123,000 |
| Cash From Operating Activities | -372,977,000 | -389,841,000 | -296,062,000 |
| Purchases Of Marketable Securities | 641,759,000 | 1,542,433,000 | 417,930,000 |
| Sales Of Marketable Securities | 1,033,259,000 | 818,383,000 | 674,679,000 |
| Acquisition Of Property Plant And Equipment | 4,316,000 | 1,685,000 | 999,000 |
| Acquisition Of Business | — | — | — |
| Other Investing Activities | — | — | — |
| Cash From Investing Activities | 377,184,000 | 363,441,000 | 239,575,000 |
| Tax Withholding For Share Based Compensation | — | — | — |
| Payments Of Dividends | — | — | — |
| Issuance Of Common Stock | — | — | — |
| Repurchase Of Common Stock | — | — | — |
| Issuance Of Long Term Debt | — | — | — |
| Repayment Of Long Term Debt | — | — | — |
| Other Financing Activities | 8,676,000 | 14,442,000 | 5,433,000 |
| Cash From Financing Activities | 8,676,000 | 14,442,000 | 5,433,000 |
| Change In Cash | 12,883,000 | -11,958,000 | -51,054,000 |
| Cash At End Of Period | 89,130,000 | 76,247,000 | 88,205,000 |
| Income Taxes Paid | 628,000 | 43,150,000 | 1,569,000 |
| Interest Paid | — | — | — |
| Fiscal Year | 2025 | 2024 | 2023 |
|---|---|---|---|
| Earnings Per Share | -7.12 | 11.86 | -6.33 |
| Price To Earnings Ratio | -3.823 | 2.7707 | -3.5182 |
| Earnings Growth Rate | -160.0337 | -287.3618 | 49.6454 |
| Price Earnings To Growth Ratio | 0.0239 | -0.0096 | -0.0709 |
| Book Value Per Share | 20.5809 | 27.126 | 14.5732 |
| Price To Book Ratio | 1.3226 | 1.2114 | 1.5281 |
| Ebitda | -406,953,000 | 722,575,000 | -343,919,000 |
| Enterprise Value | — | — | — |
| Dividend Yield | — | — | — |
| Dividend Payout Ratio | — | — | — |
| Debt To Equity Ratio | — | — | — |
| Capital Expenditures | 4,300,000 | 1,993,000 | -1,005,000 |
| Free Cash Flow | -377,277,000 | -391,834,000 | -295,057,000 |
| Return On Equity | -0.346 | 0.4372 | -0.4341 |
| One Year Beta | 0.9248 | 1.5839 | 1.1323 |
| Three Year Beta | 1.1179 | 1.4547 | 1.2891 |
| Five Year Beta | 1.2261 | 1.0827 | 1.0962 |
| Insider Name | Relationship To Issuer | Transaction Date | Amount Of Securities | Acquired Or Disposed | Securities Owned Following Transaction |
|---|---|---|---|---|---|
| Milanova Tsveta | Chief Commercial Officer | 2026-01-05 | 8,475 | A | 37,665 |
| Milanova Tsveta | Chief Commercial Officer | 2026-01-05 | 2,872 | D | 34,793 |
| Milanova Tsveta | Chief Commercial Officer | 2026-01-05 | 8,475 | D | 0 |
| Milanova Tsveta | Chief Commercial Officer | 2025-12-30 | 6,000 | A | 32,122 |
| Milanova Tsveta | Chief Commercial Officer | 2025-12-30 | 2,932 | D | 29,190 |
| Name Of Reporting Person | Report Date | State | Transaction Type | Transaction Date | Owner Type | Amount |
|---|---|---|---|---|---|---|
| Gilbert Cisneros | 2026-01-12 | CA31 | Purchase | 2025-12-11 | — | $1,001 - $15,000 |
| Gilbert Cisneros | 2025-05-06 | CA31 | Purchase | 2025-04-17 | — | $1,001 - $15,000 |
| Gilbert Cisneros | 2025-02-11 | CA31 | Purchase | 2025-01-29 | — | $1,001 - $15,000 |
| Josh Gottheimer | 2024-02-15 | NJ05 | Purchase | 2024-01-24 | Joint | $1,001 - $15,000 |
| Thomas MacArthur | 2015-06-07 | NJ03 | Sale | 2015-05-27 | Joint | $1,001 - $15,000 |
| Investor Name | Period Of Report | Market Value | Amount Of Securities | Price Per Security |
|---|---|---|---|---|
| Ikarian Capital, LLC | 2025-12-31 | 3,734,584 | 137,200 | 27.22 |
| Ikarian Capital, LLC | 2025-12-31 | 3,143,611 | 115,489 | 27.22 |
| Freestone Grove Partners LP | 2025-12-31 | 1,111,692 | 40,841 | 27.22 |
| Caligan Partners LP | 2025-12-31 | 2,449,800 | 90,000 | 27.22 |
| ADAR1 Capital Management, LLC | 2025-12-31 | 5,117,360 | 188,000 | 27.22 |
| Registrant Name | Period Of Report | Fund Name | Fund Symbol | Amount Of Units | Value In Usd | Percentage Value Compared To Assets |
|---|---|---|---|---|---|---|
| Global X Funds | 2025-11-30 | Global X Aging Population ETF | AGNG | 7,249 | 211,670.8 | 0.2786 |
| ALPS ETF Trust | 2025-11-30 | ALPS Medical Breakthroughs ETF | SBIO | 25,453 | 743,227.6 | 0.7105 |
| SEI INSTITUTIONAL INVESTMENTS TRUST | 2025-11-30 | SIIT Extended Market Index Fund - Class A | SMXAX | 7,900 | 230,680 | 0.0191 |
| SEI INSTITUTIONAL INVESTMENTS TRUST | 2025-11-30 | SIIT Multi-Asset Real Return Fund - Class A | SEIAX | 229 | 6,686.8 | 0.0009 |
| Invesco Exchange-Traded Self-Indexed Fund Trust | 2025-11-30 | Invesco Russell 2000(R) Dynamic Multifactor ETF | OMFS | 4,311 | 125,881.2 | 0.0488 |